Denver-based startups that raised in the last 12 months and are actively hiring
Cascade develops a scalable enzyme-stabilization platform ("Body Armor for Enzymes") that extends enzyme lifetimes for cell-free biomanufacturing, accelerating reactions and simplifying downstream processing across chemical, flavor, food, and pharma.
cascade-biocatalysts.breezy.hrStrive Health is a value-based kidney care provider that combines AI-powered predictive analytics, specialized nephrology clinicians, and integrated care platforms to manage CKD-to-ESKD care across payor and provider networks.
job-boards.greenhouse.ioRADICL Defense provides an AI-native virtual security operations center (vSOC) that delivers cybersecurity-as-a-service to SMBs in high-risk, highly regulated sectors.
ats.rippling.comRespondology provides an AI-powered Comment Activation Platform that moderates social media comments in real time, removes toxic/spam/bot content across 100+ languages, and extracts sentiment and trend insights.
ats.rippling.comzLinq offers telecom lifecycle management software and services that help mid-size enterprises select, deploy, manage, and optimize their voice and data networks.
getzlinq.comEnveda uses an AI-powered metabolomics platform combining machine learning, transformer models, robotics, and high-throughput chemistry to map natural-product chemical space, identify small-molecule candidates, and advance them to clinical trials.
jobs.lever.coNeuramint offers a visual AI agent platform that lets developers build and manage autonomous Web3 workflows across multiple blockchains without complex smart-contract coding.
Pluto Biosciences is a cloud-based, no-code life sciences platform that centralizes experimental data, auto-scaling bioinformatics pipelines, interactive publication-ready visualizations, role-based access, and R&D integrations across diverse assay types.
pluto.bioRIFD operates a Shariah-compliant platform that securitizes corporate receivables to provide institutional-grade supply chain financing infrastructure for SME suppliers across Saudi Arabia and the MENA region.
Demand AI Group is a Denver-based company that delivers AI-powered B2B demand-generation, lead-generation and content-marketing solutions to enterprise clients worldwide.
demandai.netStarRez provides cloud-based software that manages on- and off-campus student housing operations for universities and property managers worldwide.
job-boards.greenhouse.ioNextFoods is a Boulder-based parent company of Cheribundi and GoodBelly that develops functional wellness food and beverage products aimed at gut health, recovery, and sleep.
Rebound Technologies is an energy startup that builds the IcePoint thermal energy storage system, which generates and stores cooling during off-peak hours for use during periods of high demand.
rebound-technologies.breezy.hrDakota is a crypto-integrated business banking platform enabling companies to hold and transfer USD and stablecoins via ACH, Fedwire, SWIFT, SEPA, with blockchain settlements, corporate cards and international onboarding.
jobs.ashbyhq.comCometChat is an in-app communication platform that enables businesses to build and deploy conversational AI agents without code.
careers.cometchat.comQuantinuum develops and integrates quantum hardware, software, developer tools and applications (e.g., InQuanto) and builds next‑generation systems (Helios) while partnering with industry and research centers globally.
jobs.eu.lever.coCrusoe Energy Systems is an AI infrastructure company that builds and operates energy-efficient, high-performance cloud data centers for AI workloads.
jobs.ashbyhq.comNude Foods Market is a Boulder-based grocery store that sells products in returnable glass jars and reusable containers to eliminate single-use packaging.
nudefoodsmarket.comLux Aeterna builds reusable satellite platforms with integrated heat shields that allow satellites and their payloads to safely return to Earth.
luxaeterna.applytojob.comBoom Supersonic is developing supersonic commercial aircraft and has spun out a natural-gas turbine product to finance its aviation ambitions.
boomsupersonic.comNira Energy is a Denver-based provider of transmission automation software that automates interconnection analysis and portfolio optimization for solar, storage, and data center developers across U.S. power markets.
job-boards.greenhouse.ioCircadence provides AI-driven cyber readiness, threat modeling, and cyber range solutions for defense, intelligence, and enterprise customers.
circadence.comDeduction provides an AI-powered tax preparation platform that aims to eliminate costly, slow CPA interactions.
Navidence provides an AI-native platform and services that standardize and streamline the use of real-world health data for clinical research through its Computable Operational Definitions (CODefs).
navidence.comVieCure develops an AI-powered clinical decision-support and oncology electronic medical record platform that helps community cancer clinics deliver precision medicine at scale.
viecure.comFreeplay provides a model-agnostic platform and web dashboard for AI teams to build and deploy LLM-powered apps, offering prompt/model management, automated evaluations, data-labeling workflows, playgrounds, batch testing, and observability.
jobs.ashbyhq.comNova Sky Stories operates drone-based entertainment, creating original characters and narratives for interactive aerial stadium shows using a scaled fleet acquired from Intel while building IP for family performances.
HapWare is a Colorado-based assistive technology startup developing AlEye, a wearable system that translates nonverbal social cues into real-time haptic feedback for people who are blind, low-vision, deaf-blind and neurodiverse.
jobs.techstars.comFoodHealth provides a nutrition intelligence platform with a FoodHealth Score (1–100) that evaluates nutrient density and ingredient quality, embedded across retail channels and licensed to supermarkets, menus and cafeterias.
Simplifya provides regulatory and operational compliance software for the U.S. cannabis and hemp industries.
simplifya.comencoord provides SAInt, a unified software platform that enables utilities and other grid stakeholders to conduct integrated financial and operational grid planning.
encoord.comZcash Open Development Lab (ZODL) is a commercial spinout of the original Zcash development team building the Zodl self-custody privacy wallet and advancing Zcash protocol development.
jobs.ashbyhq.comComeryx is a Denver-based, AI-native digital Managing General Agent (MGA) providing excess & surplus insurance to small-business artisan contractors.
Orion provides an AI-powered risk intelligence platform that predicts and quantifies real-world threats for enterprises and defense teams.
Burstverse is a Web3 AI platform using AI agents and a conversational interface to translate natural-language commands into multi-chain token swaps, staking, cross-chain bridging, and an LLM-native wallet.
Noma Therapy is a Denver-based telehealth provider delivering insurance-covered, evidence-based ketamine-assisted psychotherapy with combined therapy and medication management for depression, anxiety, PTSD, in-network with major insurers and federal programs.
StackHawk provides a developer-first application and API security testing platform that integrates automated DAST powered by OWASP ZAP into CI/CD and developer workflows for continuous vulnerability scanning and remediation.
VitriVax develops a thermostable, single-shot vaccine formulation platform called ALTA® to improve global vaccine distribution and access.
vitrivaxbio.comLin Health provides a virtual, neuroscience-based chronic pain recovery platform that partners with payers and providers to deliver non-opioid, evidence-based care.
Two Boxes is a Denver-based company that provides an AI-powered returns processing platform for retailers and logistics providers.
twoboxes.comRheumaGen is a Colorado-based biotech developing one-time, HLA-edited cell and gene therapies to cure common autoimmune diseases.
Transverse Medical develops POINT‑GUARD cerebral embolic protection for TAVR and other transcatheter procedures, conducting TGA feasibility trials and scaling engineering, regulatory, quality, and operations toward FDA IDE submission.
CisLunar Industries is a Loveland, Colorado-based company that delivers flight-proven power hardware and software for the space industrial economy.
cislunarindustries.comElectra is a Boulder-based clean iron technology company that uses electricity and chemistry to convert diverse iron ores into 99% pure iron for green steel, batteries, and advanced applications.
job-boards.greenhouse.ioW3.io is a Web3 infrastructure company building the Prodigy Network, a programmable automation layer that composes network partners into configurable 'recipes' for creator payments and business workflows.
Halfdays is a Colorado-based, women-led outdoor apparel brand that makes performance-driven skiwear, trail, and active clothing for women.
halfdays.comSensera Systems provides AI-powered jobsite intelligence for construction through solar-powered, wirelessly connected camera hardware and cloud software.
senserasystems.comVero Networks designs, builds, owns and operates fiber infrastructure that delivers high-speed broadband and wholesale connectivity services across the United States.
veronetworks.applytojob.comAtolio provides a fully private, AI-powered enterprise search platform deployable on-premises or in private clouds to connect siloed systems, surface organizational knowledge, and improve product and customer information accessibility.
jobs.ashbyhq.comSTACK Infrastructure is a wholesale colocation provider that develops and operates large-scale, sustainable data center campuses across APAC and other regions.
stackinfra.comMGT Insurance is a San-Francisco-based vertically AI-native neo-insurer modernizing commercial P&C insurance for small businesses and their agents.
job-boards.greenhouse.ioThinkOrbital is a Boulder-based startup developing on-orbit X-ray imaging, inspection, and autonomous construction technologies to enable large-scale space infrastructure.
thinkorbital.comZero Homes provides a digital marketplace and platform that enables homeowners to plan, quote, and schedule residential electrification retrofits through a mobile app–based virtual assessment.
zerohomes.comGreat Sky is a company developing a brain-inspired superconducting optoelectronic computing architecture for next-generation AI.
Endolith develops AI-directed biomining technology that harnesses specialized microbes to sustainably extract critical minerals from low-grade or complex ores.
careers.nucleus-capital.comThink Bioscience is a Boulder-based biotechnology company using synthetic biology to discover small-molecule drugs for historically undruggable targets.
thinkbioscience.comPeregrine Energy Solutions is a Boulder-based developer and operator of utility-scale battery storage and grid reliability projects.
peregrineenergysolutions.comAmbrosia Biosciences is a drug discovery company developing orally delivered small-molecule therapies for obesity and other metabolic disorders.
ambrosiabiosciences.comGreen Steel Environmental develops chemical-free wastewater and biogas treatment technologies enabling utilities to manage treatment systems without toxic compounds, reducing handling risks and environmental impacts.
Bedrock Research provides an AI-powered geospatial intelligence platform that fuses sensor-agnostic imagery, AIS, thermal, FMV, and open-source feeds, applying anomaly detection and semantic annotation for rapid, configurable monitoring.
Splash Sports is a Denver-based skill-based social sports gaming platform that lets fans create and compete in real-money peer-to-peer contests across major sports leagues.
wellfound.comBoostie is an automated talent-marketing platform that enables staffing agencies and corporate recruiting teams to attract, engage, and convert candidates by activating the data already in their ATS and career sites.
New Iridium develops ethanol-oxidation and light-driven photocatalysis processes that convert first-generation bioethanol and CO2 into bio-based acetic acid and ethyl acetate using existing ethanol infrastructure.
Vantage Data Centers develops, builds and operates hyperscale data center campuses worldwide, delivering power, cooling (including direct-to-chip liquid), protection and connectivity for cloud, AI and large enterprise customers.
vantage-dc.comMaybell Quantum builds cryogenic and RF platforms (Fridge, Big Fridge) providing sub-Kelvin cooling, integrated wiring, and MayQ Labs to enable higher qubit counts, lower error rates, and manufacturing
job-boards.greenhouse.ioAvanoo provides a platform that continuously maps and analyzes enterprise SaaS and AI tool usage to detect shadow IT, reduce costs, and improve compliance.
Flock operates a 721 Exchange-based platform that buys landlords' properties in exchange for fund shares, owns and manages diversified rental portfolios (single-family, multifamily, manufactured), and standardizes valuations and repairs.
job-boards.greenhouse.ioLightTable uses AI to analyze design and engineering PDFs, producing coordinated constructability, MEP, accessibility and fire-safety reviews and flagging issues that could cause construction delays or change orders.
lighttable.aiNorthslope builds mission-specific applied-AI software natively on the Palantir operating system for enterprise customers across critical industries.
northslope.comBifrost Electronics develops magnetically insensitive, scalable electro‑optic quantum amplifiers and quantum readout hardware for superconducting and spin qubits, manufactured in the U.S. and integrated with existing quantum stacks.
Backflip is a real-estate fintech platform that provides technology, data and capital to help entrepreneurs source, analyze and finance single-family housing investments.
jobs.ashbyhq.comTwo Prime is an SEC-registered investment advisor and institutional lender providing institutions bespoke bitcoin derivatives, yield and lending solutions, serving corporate treasuries, miners, family offices with operational transparency.
wellfound.comHRSoft provides a low-code enterprise software platform that helps large organizations manage complex global compensation programs with structure, flexibility, and auditability.
hrsoft.comWillie's Remedy+ produces hemp-derived THC-infused beverages positioned as a modern, hangover-free alternative to alcohol.
Quantix provides an IT workforce management and specialist staffing platform that places and manages technical talent for enterprises in healthcare, fintech, government, and other regulated industries.
careers.smartrecruiters.comGravity is an AI analytics company building Orion, an AI analyst that continuously investigates data and surfaces insights.
True Anomaly designs and manufactures autonomous spacecraft (Jackal) and the Mosaic autonomy software, providing rendezvous and proximity operations, non-Earth imaging, operator training, and rapid-response on-orbit mission services.
trueanomaly.spaceBarrell Lithium LLC is a Texas company formed in 2024 by Barrell Energy to explore and develop lithium brine resources in the Smackover Formation of East Texas.
Alta Resource Technologies uses immobilized engineered proteins on resin columns to selectively capture and release rare earths and other critical metals from ores, tailings, and electronic waste.
altatech.ioFieldFlo provides cloud-based project, safety, and compliance management software tailored to high-risk specialty subcontractors.
fieldflo.comModii provides a cloud platform that aggregates real-time parking utilization data and applies AI analytics to predict demand, optimize enforcement, pricing, and operations across one million parking spaces.
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