Chicago-based startups who've raised in the last year and are currently hiring
Switched Source develops advanced power-electronics solutions that modernize and strengthen electric distribution grids for utilities and microgrids.
GeoWealth is a proprietary technology and asset management platform provider offering an asset management platform and financial technology solutions for modern RIAs.
Pimly is a Chicago-based startup offering the first Salesforce-native Product Cloud that unifies product, commerce, and CRM data for enterprises.
Blue Health Intelligence offers comprehensive 60-minute preventive health checks outside the traditional healthcare system.
Argentum AI operates a decentralized marketplace that connects enterprises needing high-performance computing with providers of idle GPU and other compute resources.
Graymatter is a Chicago-based consumer mental-wellness startup that sells plant-based nootropic drink mixes designed to make daily brain supplementation a mainstream habit.
Theta Neurotech develops wearable patches that monitor and stream non-invasive EEG brain signals to a paired mobile app and apply patient-specific machine learning to detect shifts preceding epileptic seizures.
Cresco Labs produces pharmaceutical-grade medical and adult-use cannabis products (brands: Cresco, Remedi, Reserve, Mindy’s Edibles), operating vertically integrated cultivation and dispensary operations across six U.S. states.
LYLA is a tech-driven concierge service platform focused on the health care sector, particularly senior care.
The Partner Companies is a U.S.-based advanced manufacturing platform operating 11 specialty brands that serve aerospace, defense, med-tech, energy and other industries.
Nurture Life prepares and ships dietitian-designed meals and snacks for babies, children from a 30,000 sq ft SQF-certified Bedford Park facility, operating seven days with prep, production, fulfillment teams.
Stately Bio builds an ML-driven, label-free live-cell imaging platform that identifies and tracks cells over time to quantify differentiation, optimize protocols, and forecast manufacturing QC outcomes for regenerative medicine.
Coinflow is a Chicago-based payment service provider that unifies stablecoins, AI-driven fraud prevention, and blockchain proof-of-delivery to enable instant global pay-ins and payouts.
Sphera provides integrated SaaS software, data and consulting that help global enterprises manage environment, health, safety and sustainability-related operational risks.
Madison Scientific develops the SmartShunt system—an electro‑mechanical shunt combining a proprietary valve, intracranial pressure sensor, and algorithms to integrate diagnostics and optimize hydrocephalus drainage and management.
Hub is a global insurance brokerage and financial services firm serving middle and upper‑middle markets, offering industry- and product-specific risk management, brokerage, proprietary products, digital solutions, and distribution channels.
Letter AI provides an AI-native revenue enablement platform that delivers real-time, deal-specific guidance to enterprise sales teams.
Mode Mobile operates a fintech-media rewards platform (EarnPhones) that enables consumers to monetize smartphone time and attention and works with media partners to scale national user acquisition.
Renterra provides an AI-driven, all-in-one software platform that powers and modernizes operations for equipment rental businesses.
KOR is a US-based fintech that provides trade and transaction reporting technology and operates licensed global derivatives trade repositories.
NEWITY is a Chicago-based fintech marketplace that uses AI to connect small businesses with SBA 7(a) and other growth loans.
Neocol implements and manages Salesforce-based revenue systems—CPQ & Billing, B2B Commerce, contract and order management, billing and revenue recognition—and integrates AI agents for subscription and B2B go-to-market operations.
Metopio provides a community intelligence platform that automates CHA/CHIP workflows, offers instant trend analysis, interactive maps, customizable dashboards, report generation, and AI-powered analytics across thousands of U.S. datasets.
Mahalo provides an end-to-end post-purchase experience platform for small and midsize manufacturers, using generative AI‑powered customer portals to automate troubleshooting, warranty claims/registrations, workflows, and follow-on purchases.
Breakbeat Media produces and distributes hip‑hop–focused podcasts and video series across YouTube, social platforms, and audio apps, and expands into subscriptions, advertising, touring, and documentary and new media formats.
Unvale is a social publishing platform where storytellers build fictional worlds, grow audiences, and self-publish across novels, comics, and animation.
XP operates a fan-focused ticket marketplace offering concerts, sports, and shows with transparent fair-market pricing, Price Alerts and Tixpy comparison tools, plus AI- and blockchain-enabled identity features for rewards.
Sprocket Sports provides an all-in-one SaaS platform that streamlines registration, payments, communications, websites and mobile engagement for youth sports clubs.
ghSMART provides leadership advisory and executive assessment services to CEOs, boards, investors, and organizations, delivering C-suite search, leadership-team development, succession planning, and organizational decision support.
Avant is a financial technology company that provides personal loans and credit cards to middle-income consumers through a data-driven, machine-learning platform.
Kin operates a direct-to-consumer, agentless homeowners insurance platform that uses thousands of property data points to underwrite, price, issue policies through customer-owned reciprocal exchanges and handle digital claims.
Syntax Bio is a synthetic biology company that uses its CRISPR-based Cellgorithm™ platform to rapidly program stem cells into therapeutic cell types for next-generation regenerative medicines.
Certiverse provides an AI-guided online test development platform that applies psychometric standards and machine learning to enable asynchronous SME collaboration, scalable valid exam creation, and faster certification delivery.
Architect is a Chicago-based fintech that operates AX, a Bermuda-regulated centralized exchange offering perpetual futures on traditional asset classes to institutional traders.
SafeHill is a Chicago-based cybersecurity startup that provides an AI-enhanced Continuous Threat Exposure Management platform for enterprises.
Trading Technologies is a company that has secured an investment from Thoma Bravo.
Pulse Charter Connect provides healthcare logistics and coordination for organ and surgical team transport, using real-time data and automation to minimize delays and streamline the organ transplant workflow.
Bonside is a New York-based credit platform that provides AI-driven revenue-based financing to brick-and-mortar service businesses.
Fulfiller is an Olivet-based online printing platform that supplies a wide range of promotional and communication materials to professional clients through its own plant and a network of partner print shops.
KeyCare provides Epic-based virtual care solutions that integrate with health systems to expand access to coordinated, high-quality patient care.
ElectronX is a Chicago-based regulated energy exchange creating a direct-access power derivatives market for precision risk management in U.S. electricity.
Zero Hash provides regulatory-compliant APIs that let businesses integrate crypto, stablecoin and tokenization functionality into their products.
Qumis offers an attorney-trained AI platform that delivers commercial insurance coverage intelligence for brokers, carriers, and law firms.
Whale is a Chicago-based fintech platform that turns rental security deposits into lockable, high-yield, FDIC-insured savings accounts while removing deposit-management burdens for multifamily property owners.
Zarminali Pediatrics operates a tech-enabled, integrated pediatric care network that delivers coordinated primary, specialty, and urgent care through clinics and telehealth nationwide.
Abacus is a Chicago-based software company specializing in secure AI and enterprise search solutions for regulated industries, including financial services. We build locally-run LLMs and encrypted messaging that prioritize data privacy and seamless integration with existing systems. Founded April 12, 2018, our team focuses on compliance-aware AI, tailored deployments, and hands-on support. Book a demo to see how Abacus can secure and simplify your organization’s knowledge and workflows."
google.comVinyl Equity is a SEC-registered transfer agent providing a cloud-native platform for share registry, dividend management, proxy voting, compliance, and AI-driven automation for shareholder records and document verification.
HOPPR provides a platform for developers and PACS vendors to fine-tune, validate, deploy foundation models for medical imaging with secure pipelines, curated datasets, traceable provenance, clinical readiness tooling.
Sligo AI builds secure, enterprise-grade autonomous AI agents that reconstruct procurement workflows for large enterprises.
Bruce Markets operates Bruce ATS, offering institutional-grade overnight trading of U.S. securities from 8:00 p.m.–4:00 a.m. ET, Sunday through Thursday, extending market access beyond regular hours.
Grove Biopharma builds a platform combining polymer, peptide and medicinal chemistry with AI-driven computational chemistry and protein engineering to produce synthetic, cell-penetrant drugs targeting intracellular oncology and neurodegenerative proteins.
Chowbus is an AI-powered platform that equips culturally rooted, independent restaurants with integrated POS, marketing, and management tools.
Amphix Bio develops supramolecular peptide therapeutics to treat neurological injuries and neurodegenerative diseases.
Bishop Street Underwriters is a fast-growing MGA platform that supports elite underwriters, acquires complementary businesses, and launches new insurance programs.
Empirical Security builds AI/ML cybersecurity intelligence with a dual-model architecture—global models trained on internet-scale exploitation events and customer-specific local models fine-tuned for evidence-based, localized risk analysis and prioritization.
Waterly provides a platform for small-to-mid utilities and operators to digitize water and wastewater plant operations, reporting, asset management, visualization and analytics, and integrate sampling, chain-of-custody, and lab data.
Auxira Health is a Chicago-based virtual cardiology company that embeds remote clinical teams into existing cardiology practices to expand capacity and improve patient access.
Prenosis is a Chicago-based biology-driven technology company using deep data and AI to deliver integrated diagnostics and therapeutics, including the FDA-authorized Sepsis ImmunoScore.
Priceagent is a self-serve platform that runs price-sensitivity tests using real consumer feedback and a proprietary algorithm to map willingness-to-pay, demand curves, price walls, and competitor benchmarks across markets.
SynchNeuro is a Philadelphia-based health-tech startup building a non-invasive brain-signal platform that translates EEG data into real-time cardiometabolic and glucose insights.
Chainsight is a Chicago-based firm that uses AI to provide supply-chain planning and integration services for global enterprises.
Cuesta Partners is an AI and data technology advisory firm that helps middle-market companies embed AI-driven automation and analytics across finance and operations.
Ocient builds an ultra-large-scale relational database and analytics platform that enables interactive, sub-second queries, billions-rows-per-second ingestion, in-database ML and geospatial processing across on-premises, OcientCloud, and public clouds.
Go Brewing produces award-winning non-alcoholic craft beers distributed across 32 U.S. states and 8,000+ retail locations.
DUDE Wipes is a Chicago-based personal hygiene company that manufactures and sells flushable wipes nationwide through retailers including Amazon, Kroger, Publix, Sam’s Club, Target, and Walmart.
Amylu Foods is a Chicago-based manufacturer of all-natural, value-added chicken products—sausages, meatballs, burgers—offering nearly 50 organic, antibiotic- and nitrate-free branded and private-label varieties for retail channels.